Ingredient Information
Summary
Cholecalciferol, also known as vitamin D3, is a fat-soluble vitamin essential for maintaining healthy bones and teeth. It helps the body absorb calcium and phosphorus, contributing to normal bone and muscle function. Cholecalciferol is produced in the skin through sunlight exposure, but it can also be obtained from dietary sources like oily fish, egg yolks, and fortified foods, or through supplements. People who may benefit from cholecalciferol include those with limited sun exposure, older adults, and individuals with darker skin, as they may have difficulty producing enough vitamin D naturally. Ensuring adequate levels of cholecalciferol supports overall health and well-being.
Key Facts
- Type: Vitamin (Vitamin D3)
- Natural source: Sunlight exposure, fish liver oils, egg yolks
- Typical supplemental dose: 10 µg (400 IU), 200% NRV
- Used for: Contributes to normal immune system function
- First discovered: 1920s
What Is Cholecalciferol?
Cholecalciferol, commonly known as Vitamin D3, is a fat-soluble vitamin with the empirical formula C27H44O. It is classified as a secosteroid, a type of steroid with a broken ring. Typically, it appears as a white, crystalline powder. Cholecalciferol is sourced from lanolin in sheep’s wool or fish liver oils and can also be synthesised through ultraviolet irradiation of 7-dehydrocholesterol. It plays a crucial role in maintaining normal blood calcium levels, contributing to the normal function of the immune system and the maintenance of normal bones.
How It Works In The Body
Cholecalciferol (vitamin D3) is converted in the liver to calcidiol (25-hydroxyvitamin D), which is then transformed in the kidneys into calcitriol (1,25-dihydroxyvitamin D), the active form. Calcitriol helps regulate calcium and phosphate levels in the body, contributing to normal bone health and immune function.
Safety & Interactions
- Cholecalciferol (Vitamin D3) is generally recognised as safe when consumed within recommended amounts.
- Individuals with hypercalcaemia or severe renal impairment should avoid cholecalciferol unless advised by a healthcare professional.
- Pregnant or breastfeeding women should consult a healthcare provider before taking high doses of cholecalciferol.
- The UK upper intake level for cholecalciferol is 100 µg (4000 IU) per day for adults.
- Excessive intake of cholecalciferol can lead to hypercalcaemia, which may cause symptoms like nausea, vomiting, and weakness.
Always consult your health practitioner before taking nutritional supplements, especially if you are taking medication or are under medical supervision. You should not take supplements as a substitute for a varied balanced diet or healthy lifestyle.
FAQs
What is Cholecalciferol?
Cholecalciferol is a form of vitamin D, also known as vitamin D3. It contributes to the maintenance of normal bones and teeth, supports normal muscle function, and plays a role in the normal function of the immune system.
How should I take Cholecalciferol supplements?
We recommend following the dosage instructions on the product label or as advised by a healthcare professional. It’s important not to exceed the recommended daily intake.
Can Cholecalciferol help with calcium absorption?
Yes, Cholecalciferol contributes to the normal absorption and utilisation of calcium and phosphorus, which are essential for maintaining healthy bones and teeth.
References
1. https://pubmed.ncbi.nlm.nih.gov/31747175/
Cholecalciferol is a dietary supplement indicated for patients with vitamin D insufficiency or deficiency
2. https://pubmed.ncbi.nlm.nih.gov/32486496/
Cholecalciferol has more scientific evidence with positive results than calcifediol in musculoskeletal diseases and is the form of vitamin D of choice in the management of osteoporosis.
3. https://pubmed.ncbi.nlm.nih.gov/39861407/
Vitamin D, primarily in the form of cholecalciferol, offers numerous health benefits beyond musculoskeletal health, including cardiovascular health and immunity.
Where next?
Information on this page is for educational purposes only and is not a substitute for personalised medical advice. Always consult a healthcare professional before making dietary changes or starting new supplements.